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折扣/货期| 货号：AG-40B-0138-C050 | 规格：50 ug | 目录价：￥3480 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
Fc (human):Dectin-1 (mouse) (rec.)
别名:
C-type Lectin Domain Family 7 Member A; Beta-Glucan Receptor; Dendritic Cell-associated C-type Lectin 1; C-type Lectin Superfamily Member 12; DC-associated C-type Lectin 1
产品描述:
Dectin-1 and dectin-2 are type II transmembrane proteins of the C-type lectin family. They contain single carbohydrate recognition domains (CRDs) in their extracellular region. Dectin-1 and dectin-2 are expressed in macrophages and dendritic cells. Dectin-1 recognizes beta-glucans with its CRD and signals through its immunoreceptor tyrosine-based activation motif (ITAM)-like motif in the cytoplasmic domain, whereas dectin-2 recognizes alpha-mannans and transduces its signal through association with the ITAM-containing Fc receptor gamma-chain. Dectin-1 controls fungal infection by sensing beta-glucans and by mounting a Th17-mediated immune responses. Dectin-1 seems to detect also non-fungal ligands such as invertebrate tropomyosin. Dectin-1 by binding to non-fungal ligands controls type 2 immunity in the lungs in response to the dust mite aeroallergen through the regulation of IL-33-driven IL-13 production from innate lymphoid cells.
宿主来源:
HEK 293 cells
产品浓度:
1mg/ml after reconstitution
保存温度:
+4°C
运输温度:
BI
预期分子量:
~56kDa (SDS-PAGE)
产品形式:
solid
存储溶液:
Lyophilized. Contains PBS.
产地:
瑞士
纯度:
>95% (SDS-PAGE)
内毒素水平:
<0.01EU/µg purified protein (LAL test).
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