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折扣/货期| 货号：GTX70185 | 规格：100μl | 目录价：￥4300 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
FEN1 antibody [4E7]
别名:
flap structure-specific endonuclease 1 , FEN-1 , MF1 , RAD2
反应种属:
Human, Mouse
宿主来源:
Mouse
实验应用:
ChIP assay, ICC/IF, IP, WB
靶标/特异性:
KO/KD validation is based on published data (PMID: 29928064).
同种型:
IgG1
免疫原:
Recombinant human FEN-1 protein encoding amino acids 1-380 purified E. coli.
克隆性:
Monoclonal
克隆号:
40000000
纯化方式:
Protein G purified
偶联:
Unconjugated
产品浓度:
1.73 mg/ml (Please refer to the vial label for the specific concentration.)
保存温度:
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
运输温度:
4°C
产品形式:
Liquid
存储溶液:
PBS, no preservatives.
生产商:
GeneTex
功能与背景:
The protein encoded by this gene removes 5' overhanging flaps in DNA repair and processes the 5' ends of Okazaki fragments in lagging strand DNA synthesis. Direct physical interaction between this protein and AP endonuclease 1 during long-patch base excision repair provides coordinated loading of the proteins onto the substrate, thus passing the substrate from one enzyme to another. The protein is a member of the XPG/RAD2 endonuclease family and is one of ten proteins essential for cell-free DNA replication. DNA secondary structure can inhibit flap processing at certain trinucleotide repeats in a length-dependent manner by concealing the 5' end of the flap that is necessary for both binding and cleavage by the protein encoded by this gene. Therefore, secondary structure can deter the protective function of this protein, leading to site-specific trinucleotide expansions. [provided by RefSeq, Jul 2008]
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