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折扣/货期| 货号：AG-40A-0114Y-C010 | 规格：10 ug | 目录价：￥2280 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
FGF-23 (human) (rec.) (His)
别名:
Fibroblast Growth Factor 23; Tumor-derived Hypophosphatemia-inducing Factor
产品描述:
FGF-23 (Fibroblast growth factor 23) is a regulator of phosphate homeostasis. It upregulates EGR1 expression in the presence of KLBy. Acts directly on the parathyroid to decrease PTH secretion. Regulates the vitamin-D metabolism. Negatively regulates osteoblast differentiation and matrix mineralization. Defects in FGF-23 are the cause of autosomal dominant hypophosphataemic rickets (ADHR) and of hyperphosphatemic familial tumoral calcinosis (HFTC).
宿主来源:
HEK 293 cells
产品浓度:
0.1mg/ml after reconstitution
保存温度:
+4°C
运输温度:
BI
预期分子量:
~30kDa (SDS-PAGE, full-length). FGF23 is cleaved between Arg179 and Ser180 (two bands of ~14kDa and ~16kDa).
产品形式:
solid
存储溶液:
Lyophilized. Contains PBS.
产地:
瑞士
纯度:
>90% (SDS-PAGE)
生物活性:
Activates ERK and FRS2alpha phosphorylation in Klotho expressing cells.
内毒素水平:
<0.01EU/µg purified protein (LAL test; Lonza).
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