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折扣/货期| 货号：40-664 | 规格：10 ug | 目录价：￥3808.35 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
FGFR1a Recombinant Protein
别名:
Fibroblast Growth Factor Receptor 1 alpha, BFGFR
表达系统:
CHO cells
保存温度:
The recombinant protein is stable for at least 2 years from date of receipt at -20˚C. Reconstituted protein is stable for at least 3 months when stored in working aliquots with a carrier protein at -20˚C. As with any protein, exposing the recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.
运输温度:
Blue Ice
产品形式:
Lyophilized
产地:
美国
生产商:
Prosci
功能与背景:
The FGF family plays a central role during prenatal development and postnatal growth, and the regeneration of a variety of tissues, by promoting cellular proliferation and differentiation. The FGF ligands bind to a family of type I transmembrane tyrosine kinase receptors, which leads to dimerization and activation by sequential autophosphorylation of specific tyrosine residues. Four genes encoding structurally related FGF receptors (FGFR-1 to -4) are known. Alternative splicing of the mRNAs generates numerous forms of FGFR-1 to -3. Alternate forms of FGF receptors can exhibit different specificities with respect to ligand binding. For example, the form designated as FGFR1a (IIc) interacts predominantly with FGF-acidic (FGF1) and FGF-basic (FGF2). A frequent splicing event involving FGFR-1 and -2 results in receptors containing all three Ig domains, referred to as the alpha isoform, or only IgII and IgIII, referred to as the beta isoform. Only the alpha isoform has been identified for FGFR-3 and FGFR-4. Additional splicing events for FGFR-1 to -3, involving the C-terminal half of the IgIII domain encoded by two mutually exclusive alternative exons, generate FGF receptors with alternative IgIII domains (IIIb and IIIc). Recombinant Human FGFR1a (IIIc) is a 65.2 kDa protein containing 586 amino acids. Under reducing conditions, FGFR1a migrates between 100-110 kDa on SDS-PAGE gel.
纯度:
≥ 95% by SDS-PAGE gel and HPLC analyses.
生物活性:
Determined by a cell proliferation assay using Balb/c 3T3 cells. The expected ED50 is ≤ 0.1 ng/ml, corresponding to a specific activity of ≥ 1 x 107 units/mg.
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