FGL1 (human) ELISA Kit-人ELISA试剂盒-深圳欣博盛生物科技有限公司

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FGL1 (human) ELISA Kit

品牌：Adipogen

官网链接

说明书

折扣/货期

货号：AG-45B-0022-KI01

规格：96 wells

目录价：￥7320

产品详情

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产品名称:

FGL1 (human) ELISA Kit

别名:

Fibrinogen-like Protein 1; FGL-1; Hepatocyte-derived Fibrinogen-related Protein 1; HFREP-1; Hepassocin

产品描述:

FGL1 (Fibrinogen-like protein 1; also called Hepatocyte-derived fibrinogen-related protein 1; HFREP-1 or Hepassocin) was initially identified as an overexpressed transcript in hepatocyte carcinoma and as a transcript enriched in regenerating liver. FGL1 is expressed at lower levels in brown and white adipose in the setting of liver injury. A low level expression of FGL1 is also observed in the pancreas. FGL1 is a 34 kDa protein structurally similar to Angiopoietin-like factors 2, 3, 4 and 6, which regulate lipid metabolism and energy utilization. It was proposed that FGL1 is a member of an emerging group of proteins having potential roles in liver metabolism and liver regeneration. Recently, FGL1 has also been shown to be upregulated in human cancers and FGL1 is a major functional ligand of LAG-3. FGL1 interacts with LAG-3 in an MHC-II-independent manner and this interaction involves the FGL1 fibrinogen-like domain and the LAG-3 D1-D2 domain. FGL1-LAG-3 interaction blockade promotes tumor immunity by stimulating T cell expansion and activation. FGL1 forms two disulfide-linked homodimers and also higher molecular weight homooligomers that bind to LAG-3 much better than the dimeric forms. This binding to LAG-3 inhibits T cell responses. FGL1 is normally released by the liver in low levels but at higher levels in certain cancer such as non-small cell lung carcinomas (NSCLC) . Upregulated FGL1 in human cancers is associated with a poor prognosis.

靶标/特异性:

Detects human FGL1 in serum, plasma and cell culture supernatant.

保存温度:

+4°C

运输温度:

产地:

瑞士

灵敏度:

1.8pg/ml

检测范围:

7.8 to 500pg/ml

检测方法: