FNDC4 (human) ELISA Kit-人ELISA试剂盒-深圳欣博盛生物科技有限公司

首页产品中心人ELISA试剂盒

FNDC4 (human) ELISA Kit

品牌：Adipogen

官网链接

说明书

折扣/货期

货号：AG-45B-0028-KI01

规格：96 wells

目录价：￥7320

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

FNDC4 (human) ELISA Kit

别名:

Fibronectin Type III Domain-containing Protein 4; Fibronectin Type III Repeat-containing Protein 1; Fc Soluble FNDC4; FcsFNDC4

产品描述:

Irisin is a recently described exercise-induced hormone secreted by skeletal muscle in mice and humans. Irisin activates beige fat cells (beige cells have a gene expression pattern distinct from either white or brown fat and are preferentially sensitive to the polypeptide hormone irisin). Irisin is cleaved from the type I membrane protein FNDC5 and improves systemic metabolism by increasing energy expenditure. FNDC4 is an ortholog of FNDC5 with 50% identity and 86% similarity compared to Irisin. FNDC4 as well as FNDC5 are extremely well conserved between species. The human FNDC4 gene is highly enriched in liver, brain tissue and adipocytes. FNDC4 is a factor with direct therapeutic potential in inflammatory bowel disease and possibly other inflammatory diseases. Recently, a new role of FNDC4 as a hepatokine has been published. Liver primarily controls the circulating levels of FNDC4 showing tight correlation with insulin sensitivity. In addition, a new orphan adhesion G protein-coupled receptor 116 (GPR116) has been identified as a receptor of FNDC4 in white adipose tissue (WAT), thereby establishing an endocrine FNDC4-GPR116 axis in the control of systemic glucose homeostasis. Moreover, the FNDC4-GPR116 axis is impaired in diabetic patients and therapeutic injections of recombinant Fc-FNDC4 into pre-diabetic mice corrected pre-diabetic hyperglycemia. FNDC4 is a factor with direct therapeutic potential in inflammatory bowel disease and possibly other inflammatory diseases and is a potential biomarker for different inflammatory, metabolic diseases as well as some cancers (e.g. Glioblastoma).

靶标/特异性:

Detects human FNDC4 in serum, plasma and cell culture supernatant. It cross-reacts with mouse, rat, monkey and dog FNDC4. It does not cross-react with human, mouse or rat FNDC5 / Irisin.

保存温度:

+4°C

运输温度:

产品形式:

solid

产地:

瑞士

灵敏度:

40pg/ml

检测范围:

0.078 to 5ng/ml

检测方法: