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折扣/货期| 货号：79-710 | 规格：0.1 mg | 目录价：￥6493.5 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
FoxA2 (HNF3beta) Antibody
别名:
HNF3B, TCF3B, NMDAR1, HNF3B
反应种属:
Human
宿主来源:
Rabbit
实验应用:
WB
靶标/特异性:
This antibody detects endogenous level of total FoxA2 protein.
克隆性:
Polyclonal
纯化方式:
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
偶联:
Unconjugated
产品浓度:
1 mg/mL
保存温度:
Store antibody at -20˚C for up to one year.
运输温度:
Blue Ice
产品形式:
Liquid
存储溶液:
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
产地:
美国
生产商:
Prosci
功能与背景:
Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' . In embryonic development is required for notochord formation. Involved in the development of multiple endoderm-derived organ systems such as the liver, pancreas and lungs; FOXA1 and FOXA2 seem to have at least in part redundant roles. Originally discribed as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis; regulates the expression of genes important for glucose sensing in pancreatic beta-cells and glucose homeostasis. Involved in regulation of fat metabolism. Binds to fibrinogen beta promoter and is involved in IL6-induced fibrinogen beta transcriptional activation.
Accession #:
NP_068556.2
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