FOXO1 Antibody / Forkhead box protein O1-单抗-深圳欣博盛生物科技有限公司

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FOXO1 Antibody / Forkhead box protein O1

品牌：NSJ Bio

官网链接

说明书

折扣/货期

货号：V5702-100UG	规格：100 ug	目录价：￥6652.1
货号：V5702-20UG	规格：20 ug	目录价：￥3082.1

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

FOXO1 Antibody / Forkhead box protein O1

产品描述:

FKHR (for forkhead in rhabdomyosarcoma) and FKHRL1 are members of the forkhead family of transcription factors. Transcriptional activation of FKHR proteins is regulated by the serine/threonine kinase Akt1, which phosphorylates FKHRL1 and results in FKHRL1 associating with 14-3-3 proteins and being retained in the cytoplasm. Induction of apoptosis or withdrawal of growth factors stimulates dephosphorylation and nuclear translocation of FKHR proteins, leading to FKHR-induced gene-specific transcriptional activation. FKHR, also designated forkhead box protein O1A (FOXO1), is a ubiquitously expressed protein that shuttles between the cytoplasm and nucleus. Genetic mutations in FKHR genes, including the t(2;13) and t(1;3) translocations, are commonly found in alveolar rhabdomyosarcomas. These translocations result in the fusion of the amino terminus of Pax-3 or Pax-7, including the paired box and homeodomain DNA-binding domains, with the carboxyterminus of FKHR, which contains a transcriptional activation domain. The Pax-3/FKHR fusion protein appears to function as an oncogenic transcription factor that enhances the activation of normal Pax-3 target genes.

反应种属:

Human

宿主来源:

Mouse

实验应用:

IHC-P, WB

同种型:

Mouse IgG1, kappa

免疫原:

A portion of amino acids 450-650 from human FOXO1 protein was used as the immunogen for the FOXO1 antibody.

克隆性:

Monoclonal (mouse origin)