FTH Antibody / Ferritin heavy chain-单抗-深圳欣博盛生物科技有限公司

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FTH Antibody / Ferritin heavy chain

品牌：NSJ Bio

官网链接

说明书

折扣/货期

货号：V8509-100UG	规格：100 ug	目录价：￥6652.1
货号：V8509-20UG	规格：20 ug	目录价：￥3082.1

产品详情

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产品名称:

FTH Antibody / Ferritin heavy chain

产品描述:

Mammalian ferritins consist of 24 subunits made up of 2 types of poly-peptide chains, ferritin heavy chain and ferritin light chain, which each have unique functions. Ferritin heavy chains catalyze the first step in iron storage, the oxidationof FeI(II), whereas ferritin light chains promote the nucleation of ferrihydrite, enabling storage of Fe(III). The most prominent role of mammalian ferritins is to provide iron-buffering capacity to cells. In addition to iron buffering, heavy chain ferritin is also involved in the regulation of thymidine biosynthesis via increased expression of cytoplasmic serine hydroxymethyltransferase, which is a limiting factor in thymidylate synthesis in MCF-7 cells. Light chain ferritin is involved in cataracts by at least two mechanisms: hereditary hyperferritinemia cataract syndrome, in which light chain ferritin is overexpressed; and oxidative stress, an important factor in the development of aging-related cataracts.

反应种属:

Human

宿主来源:

Mouse

实验应用:

WB, IHC-P

同种型:

Mouse IgG2c, kappa

免疫原:

A portion of amino acids 58-180 from the human protein was used as the immunogen for the FTH antibody.

克隆性:

Monoclonal (mouse origin)