官网链接
折扣/货期| 货号：CDX-G0046-M100 | 规格：100 mg | 目录价：￥1666 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
Ganciclovir
别名:
2-Amino-1,9-dihydro-9-[[2-hydroxy-1-(hydroxymethyl)ethoxy]methyl]-6H-purin-6-one; 9-(1,3-Dihydroxy-2-propoxymethyl)guanine; DHPG; BW 759; 2'-Nor-2'-deoxyguanosine
产品描述:
Ganciclovir is antiviral synthetic analog of the nucleoside 2'-deoxy-guanosine, which is used to treat or prevent cytomegalovirus (CMV) infections. It acts as a prodrug activated by phosphorylation. It is first phosphorylated to ganciclovir monophosphate by a viral kinase encoded by the cytomegalovirus (CMV) gene UL97 during infection. Subsequently, cellular kinases catalyze the formation of ganciclovir diphosphate and ganciclovir triphosphate. Ganciclovir triphosphate is a competitive inhibitor of deoxyguanosine triphosphate (dGTP) incorporation into DNA and preferentially inhibits viral DNA polymerases more than cellular DNA polymerases. It is also useful in the study of gene therapy in cancer research. Ganciclovir has been used in the study of "suicide" gene therapy in cancer research, where upon expression of a viral suicide gene encoding herpes simplex virus, thymidine kinase (TK), the non-toxic prodrug ganciclovir, is converted to an active phosphorylated analog that can be incorporated into the DNA of replicating eukaryotic cells, causing death of the malignant dividing cell. Causes an irreversible cell cycle arrest at the G2/M checkpoint. Ganciclovir has also been used to study the loss of telomeres and to evaluate sensitivity of viruses to antiviral agents.
保存温度:
+4°C
运输温度:
Ambient
预期分子量:
255.23
产品形式:
solid
产地:
瑞士
纯度:
>99% (HPLC)
CAS号:
82410-32-0
分子式:
C9H13N5O4
促销活动
精品推荐
复制QQ号成功，请打开QQ后添加好友进行咨询