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折扣/货期| 货号：CDX-G0209-G001 | 规格：1 g | 目录价：￥896 |
| 货号：CDX-G0209-G005 | 规格：5 g | 目录价：￥3374 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
Gimeracil
别名:
5-Chloro-4-hydroxy-2(1H)-pyridinone; 5-Chloro-2,4-dihydroxypyridine; 5-Chloro-4-hydroxy-2-pyridone; Gimestat; CDHP
产品描述:
Gimeracil is an orally active inhibitor against dihydropyrimidine dehydrogenase (DPYD), the rate limiting enzyme for the catabolism of pyrimidines, including the chemotherapeutic drug 5-fluorouracil (5FU). It has been administered concomitantly with 5-fluorouracil in a chemotherapy regimen termed S-1 to block 5-fluorouracil degradation, thus prolonging circulating 5-fluorouracil concentrations. Furthermore, Gimeracil has been shown to inhibit homologous recombination in the repair of DNA double strand breaks, which can sensitize cancer cells to radiotherapy.
保存温度:
+4°C
运输温度:
Ambient
预期分子量:
145.54
产品形式:
solid
有效期:
Stable for at least 6 months after receipt when stored at RT.
产地:
瑞士
纯度:
>99%
CAS号:
103766-25-2
分子式:
C5H4ClNO2
溶解度:
Soluble in DMSO (25mg/ml) or DMF (20mg/ml).
促销活动
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