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折扣/货期| 货号：SPC-810D-PCP | 规格：100 µg | 目录价：￥4926.6 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
GDNF Antibody: PerCP
别名:
Glial cell line-derived neurotrophic factor Antibody, Astrocyte-derived trophic factor Antibody, Astrocyte derived trophic factor 1 Antibody, Glial cell derived neurotrophic factor Antibody, ATF 1 Antibody, ATF 2 Antibody, Glial Cell Line Derived Neurotrophic Factor Antibody, ATF Antibody, Atf Antibody, HSCR3 Antibody, Astrocyte derived trophic factor Antibody, ATF2 Antibody, GDNF_HUMAN Antibody, GDNF Antibody, Glial derived neurotrophic factor Antibody, ATF1 Antibody, gdnf Antibody, HFB1 GDNF Antibody, hGDNF Antibody
产品描述:
Rabbit Anti-Human GDNF Polyclonal
反应种属:
Human | Mouse | Rat
宿主来源:
Rabbit
实验应用:
WB
靶标/特异性:
Detects monomeric and homodimeric GDNF
推荐稀释度:
WB (1:1000); optimal dilutions for assays should be determined by the user.
免疫原:
Recombinant Human GDNF Protein, Full length (AA78-211)
免疫原种属:
Human
克隆性:
Polyclonal
纯化方式:
Protein A Purified
偶联:
PerCP
产品浓度:
1mg/mL
保存温度:
Conjugated antibodies should be stored according to the product label
运输温度:
Blue Ice or 4ºC
存储溶液:
PBS pH 7.4, 50% glycerol, 0.09% sodium azide *Storage buffer may change when conjugated
产地:
加拿大
功能与背景:
Glial cell line-derived neurotrophic factor (GDNF), a highly conserved multifunctional secretory protein, is distributed throughout the peripheral and central nervous system to support neuronal growth, proliferation, and survival (1-3). It was the first member of the GDNF family ligands (GFL). Pro-GDNF, a 211 residue precursor sequence, folds via disulphide bonding and dimerization in the endoplasmic reticulum (ER). N-linked glycosylation subsequently takes place at the tip of one of the protein’s two finger-like structures. These structures facilitate contact between the mature protein, the GRFα1 receptor, and RET, that is necessary for GDNF signalling. A similar configuration is observed in the cytokine TGFβ2 (2). The mature GDNF protein (134 residues) is produced by proteolysis of processed pro-GDNF at a proteolytic consensus sequence situated within the C-terminus (1). Through interactions between Cys131, Cys133, Cys68 & Cys72, the C-terminus forms a ring-like structure (3). As multiple proteases can cleave the precursor sequence, different forms of mature GDNF are possible (1). GDNF is implicated in the promotion of dopamine uptake within midbrain dopaminergic neurons, as well as the proliferation and migration of gliomas. Motor neurons, Schwann cells, oligodendrocytes, astrocytes, and skeletal muscle have been shown to secrete GDNF during neuronal development and growth (1,3). Initial studies suggested that GDNF may play a neuroprotective role in neurodegenerative disease such as amyotrophic lateral sclerosis (ALS), Parkinson’s disease and various synucleinopathies (4,5), however, recent research has indicated inconsistent levels of neuroprotective ability in neurodegenerative disease models (1, 6-8).
Accession #:
NP_000505.1
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