GDNF Recombinant Protein-细胞因子、趋化因子与生长因子-深圳欣博盛生物科技有限公司

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GDNF Recombinant Protein

品牌：ProSci LLC

官网链接

说明书

折扣/货期

货号：40-499-0.002 mg	规格：0.002 mg	目录价：￥3783
货号：40-499-0.01 mg	规格：0.01 mg	目录价：￥5674.5

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

GDNF Recombinant Protein

别名:

ATF1, ATF2, HSCR3, HFB1-GDNF, Glial cell line-derived neurotrophic factor, Astrocyte-derived trophic factor, hGDNF

表达系统:

E. coli

保存温度:

The lyophilized GDNF recombinant protein is stable for at least 2 years from date of receipt at -20˚C. Reconstituted GDNF is stable for at least 3 months when stored in working aliquots with a carrier protein at -20˚C. As with any protein, exposing GDNF recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.

运输温度:

Blue Ice

产品形式:

Lyophilized

产地:

美国

生产商:

Prosci

功能与背景:

GDNF is a disulfide-linked homodimeric neurotrophic factor structurally related to Artemin, Neurturin and Persephin. These proteins belong to the cysteine-knot superfamily of growth factors that assume stable dimeric protein structures. GDNF signals through a multicomponent receptor system, composed of a RET and one of the four GFRalpha (alpha1-alpha4) receptors. GDNF specifically promotes dopamine uptake and survival and morphological differentiation of midbrain neurons. Using Parkinson's disease mouse model, GDNF has been shown to improve conditions such as bradykinesia, rigidity, and postural instability. The functional human GDNF ligand is a disulfide-linked homodimer, of two 15 kDa polypeptide chains called monomers. Each monomer contains seven conserved cysteine residues, one of which (Cys 101) is used for inter-chain disulfide bridging and the others are involved in intramolecular ring formation known as the cysteine knot configuration.

纯度:

Greater than 98% by SDS-PAGE gel and HPLC analyses.

Endotoxin level is less than 0.1 ng per μg (1EU/μg).

生物活性:

Determined by a cell proliferation assay using SH-SY5Y cells. The expected ED50 for this effect is 1.0-10.0 ng/ml.

Accession #:

NP_000505.1

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