Geldanamycin- Biotin-抑制剂-深圳欣博盛生物科技有限公司

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Geldanamycin- Biotin

品牌：Stressmarq

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说明书

折扣/货期

货号：SIH-112A

规格：1 mg

目录价：￥3052.8

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

Geldanamycin- Biotin

别名:

(4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1] docosa-1(21),4,6,10,18-pentaen-9-yl carbamate

产品描述:

Hsp90 inhibitor

保存温度:

-20ºC

运输温度:

Shipped Ambient

预期分子量:

560.6

产品形式:

Purple Solid

产地:

加拿大

功能与背景:

Geldanamycin is a benzoquinoid ansamycin produced by Streptomyces hygroscopicus. It binds specifically to heat shock protein HSP90 and downregulates target proteins including tyrosine kinases, steroid receptors, transcription factors and cell cycle regulatory kinases (1,2). It induces the inactivation, destabilization and eventual degradation of HIF-1α (3). It is also an inhibitor of pp60src tyrosine kinase and of c-myc gene expression in murine lymphoblastoma cells. It inhibits the transforming activity of abl, erbB, fps, src, and yes (4). Geldanamycin is capable of destabilizing several oncogene and proto-oncogene products; it is a potent inhibitor of the nuclear hormone receptor family (5). It protects against α-synuclein toxicity to dopaminergic neurons in Drosophila, and destabilizes mutant p53 protein from a number of breast, leukemic, and prostate cell lines (6). Inhibits basal and hypoxia-induced expression of c-Jun (IC50=75nM) and abolishes hypoxia-induced increase in c-Jun N-terminal kinase (JNK) activity. Inhibits telomerase activity through inhibition of HSP90, a chaperone required for the assembly and activation of telomerase in human cells (6). It is ~10-fold more potent than herbimycin A. Looking for more information on HSP90? Visit our new HSP90 Scientific Resource Guide at http://www.HSP90.ca.

纯度:

>98%

来源:

Synthetic

CAS号:

30562-34-6

分子式:

C55H87N7O17S

溶解度:

Soluble in DMSO

PubChem CID:

5288382