Gemcitabine HCl-抑制剂-深圳欣博盛生物科技有限公司

首页产品中心抑制剂

Gemcitabine HCl

品牌：Stressmarq

官网链接

说明书

折扣/货期

货号：SIH-623-50MG

规格：50 mg

目录价：￥5140.8

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

Gemcitabine HCl

别名:

2′-Deoxy-2′,2′-difluorocytidine hydrochloride; dFdC

产品描述:

DNA polymerase inhibitor

保存温度:

-20ºC

运输温度:

Shipped Ambient

预期分子量:

299.7

产品形式:

Off-white powder

产地:

加拿大

功能与背景:

A clinically useful anticancer agent.1 It exerts its cytotoxic effects via the metabolites gemcitabine diphosphate (dFdCDP) and gemcitabine triphosphate (dFdCTP). dFdCTP is an inhibitor of DNA polymerase and is incorporated into DNA resulting in termination of chain elongation and apoptosis. dFdCDP is an inhibitor of ribonucleotide reductase which results in depletion of deoxyribonucleotides needed for DNA synthesis. The phosphates have also been reported to inhibit cytidine triphosphate synthetase (CTP synthetase)2 and deoxycytidylate deaminase (dCMP deaminase)3. Topoisomerase 1 has also been shown to be a target for gemcitabine.4

纯度:

>98% (HPLC); NMR (Conforms)

来源:

Synthetic

CAS号:

122111-03-9

分子式:

C9H11F2N3O4 • HCl

溶解度:

May be dissolved in DMSO (20 mg/ml); or Water (25 mg/ml)

PubChem CID:

60749