GFRA 1 Recombinant Protein-细胞因子、趋化因子与生长因子-深圳欣博盛生物科技有限公司

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GFRA 1 Recombinant Protein

品牌：ProSci LLC

官网链接

说明书

折扣/货期

货号：96-344

规格：0.1 mg

目录价：￥9038.25

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

GFRA 1 Recombinant Protein

别名:

GFRA1, GDNFRA, RETL1, TRNR1, GDNFR, GFR-ALPHA-1, RET1L

实验应用:

表达系统:

HEK293 cells

保存温度:

Lyophilized Protein should be stored at -20˚C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚C or -70˚C. Avoid repeated freeze-thaw cycles.

运输温度:

Blue Ice

产品形式:

Lyophilized

存储溶液:

PBS, pH7.4

产地:

美国

生产商:

Prosci

功能与背景:

GDNF family receptor alpha-1 (GFRA1) is also known as RET ligand 1 (RETL1), TGF-beta-related neurotrophic factor receptor 1 (TRNR1), is a novel glycosylphosphatidylinositol (GPI)-linked cell surface receptor, and belongs to the glial cell line-derived neurotrophic factor (GDNF) receptor subfamily. The GDNF family ligands comprises GDNF, Neurturin (NTN), Artemin, and Persephin. GDNF and NTN are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. GFRA1 mediates the association with and activation of the RET tyrosine kinase receptor (RTK), and subsequently initiates the RET signaling pathway. GFR alpha-mediated signaling plays an important role in the survival, differentiation, and migration of central and peripheral neurons, and is essential for the development of kidneys and the enteric nervous system, as well as the inflammatory response in some carciniomas.

纯度:

>95% as determined by SDS-PAGE.

生物活性:

Measured by its binding ability in a functional ELISA. Immobilized Recombinant Human GDNF at 1 μg/mL binds rhGFRA1 with an apparent KD <10 nM.

Accession #:

NP_665736.1

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