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折扣/货期| 货号：CHI-HF-210GFRAL-C100 | 规格：100 ug | 目录价：￥6160 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
GFRAL (human):Fc (human) (rec.)
别名:
GDNF Family Receptor alpha-like; Gral; Glial Cellline-derived Neurotrophic Factor Receptor alpha-like; GFR alpha-like; C6orf144
产品描述:
GFRAL (GDNF receptor alpha-like) is a distant member of the GDNFR family of proteins. Human GFR alpha-like contains a 333aa extracellular domain, a 20aa transmembrane domain and a 23aa cytoplasmic domain. Over the extracellular domain, human GFRAL shares 72% and 71% identity with mouse and rat GFRAL, respectively. It is expressed on both fetal and adult hindbrain neurons of the CNS and functions as an anti-apoptotic molecule during neuronal stress. GFRAL is a functional receptor for GDF15, facilitating weight-loss functions of the protein through c-Ret downstream signaling. GFRAL and GDF15 signaling is implicated in diet-based obesity and insulin resistance.
宿主来源:
HEK 293 cells
保存温度:
+4°C
运输温度:
BI
预期分子量:
~50-100kDa
产品形式:
solid
存储溶液:
Lyophilized from 0.2µm-filtered solution in PBS.
产地:
瑞士
纯度:
>98% (SDS-PAGE)
生物活性:
Measured by its binding ability in a functional ELISA.
内毒素水平:
<1EU/mg purified protein (LAL test; Lonza).
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