GS-441524 (Remdesivir Metabolite)-抑制剂-深圳欣博盛生物科技有限公司

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GS-441524 (Remdesivir Metabolite)

品牌：Adipogen

官网链接

说明书

折扣/货期

货号：AG-CR1-3722-M005	规格：5 mg	目录价：￥540
货号：AG-CR1-3722-M010	规格：10 mg	目录价：￥840
货号：AG-CR1-3722-M050	规格：50 mg	目录价：￥1440

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

GS-441524 (Remdesivir Metabolite)

产品描述:

GS-441524 is the active prodrug of the broad-spectrum antiviral Remdesivir. GS-441524 is an adenosine nucleotide analog in viral RNA production. It is a nucleotide analog inhibitor of RNA-dependent RNA polymerases (RdRps). The compound interferes with the action of viral RNA polymerase and evades proofreading by viral exoribonuclease (ExoN), causing a decrease in viral RNA production (RNA synthesis arrest), either by terminating RNA chains or causing mutations. It inhibits MERS-CoV or SARS-CoV-infected HAE cultures (EC50=74nM and 69nM) and murine hepatitis virus (MHV) (EC50=30nM). In vivo, remdesivir (Prod. No. AG-CR1-3713 https://adipogen.com/ag-cr1-3713-remdesivir.html ) (25 and 50 mg/kg) reduces lung viral titers and prevents weight loss in a mouse model of SARS-CoV infection. Remdesivir (Prod. No. AG-CR1-3713 https://adipogen.com/ag-cr1-3713-remdesivir.html ) is used as a treatment for Ebola virus disease and Marburg virus infections and other single stranded RNA viruses such as respiratory syncytial virus, Junin virus, Lassa fever virus, Nipah virus, Hendra virus and the coronaviruses (including MERS and SARS viruses). Remdesivir is effective in the control of 2019-nCoV (COVID-19) infection in vitro. It now also has been studied as potential treatment of SARS-CoV-2 infections.

保存温度:

+4°C

运输温度:

Ambient

预期分子量:

291.3

产品形式:

solid

产地:

瑞士

纯度:

>98% (HPLC)