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折扣/货期| 货号：AG-CR1-3628-M005 | 规格：5 mg | 目录价：￥1140 |
| 货号：AG-CR1-3628-M025 | 规格：25 mg | 目录价：￥4320 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
GSK690693
别名:
GSK-690693
产品描述:
pan-Akt inhibitor targeting Akt1, 2, 3 with IC50 values of 2, 13 and 9 nM, respectively. Inhibits AMPK, DAPK3, PAK4, 5 and 6, as well as members of the AGC kinase family including PKA, PrkX and PKC isoforms (IC50 < 100 nM). Occupies the ATP binding pocket of the kinase domain and competes with ATP. Anti-cancer compound both in vitro and in vivo. Blocks the phosphorylation of downstream targets of ATK in a dose-dependent manner, which leads to antiproliferative and apoptotic effects in tumor cell lines. Induces hyperglycemia related to peripheral insulin resistance, increased gluconeogenesis, and/or hepatic glycogenolysis.
保存温度:
+4°C
运输温度:
Ambient
预期分子量:
425.5
产品形式:
solid
有效期:
Stable for at least 2 years after receipt when stored at -20°C.
产地:
瑞士
纯度:
>95%
CAS号:
937174-76-0
分子式:
C21H27N7O3
溶解度:
Soluble in DMSO. Slightly soluble in ethanol (<1mg/ml).
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