H3K27ac Recombinant Nucleosome, Biotinylated-突变/修饰核小体-深圳欣博盛生物科技有限公司

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H3K27ac Recombinant Nucleosome, Biotinylated

品牌：EpiCypher

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说明书

折扣/货期

货号：16-0365-20

规格：20 µg

目录价：￥3540

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

H3K27ac Recombinant Nucleosome, Biotinylated

产品描述:

Histone acetylation is a post-translational modification (PTM) wherein an acetyl group is added to a lysine residue of a histone protein. In combination with other PTMs, histone acetylation constitutes the “histone code,” acting as a language read by proteins to regulate chromatin structure and gene expression. Histone acetylation is associated with gene activation and facilitates the binding of reader proteins such as SWI/SNF (BAF) chromatin remodeling complexes, BRD4, and TAF1 [1]. Recombinant nucleosomes containing acetylated histones are useful to study the biological functions of histone acetylation. H3K27ac (histone H3 lysine 27 acetylation) Recombinant Nucleosome, Biotinylated consists of 147 base pairs of 601 sequence DNA [2] wrapped around an octamer of core histone proteins (two each of H2A, H2B, H3.2, and H4) to form a nucleosome, the basic repeating unit of chromatin. The DNA contains a 5’ biotin-TEG group. H3K27ac nucleosome contains H3.2 with acetylated lysine at position 27. Histone H3.2 also contains a Cys to Ala substitution at position 110. H3K27 is acetylated by lysine acetyltransferases (KATs) such as KAT3A (CBP) and KAT3B (p300), and H3K27ac is deacetylated by lysine deacetylases (KDACs) such as HDAC1 [1].

宿主来源:

Human

表达系统:

E. coli & synthetic DNA

保存温度:

Stable for six months at -80°C from date of receipt. For best results, aliquot and avoid freeze/thaws.

运输温度:

Dry ice.

产地:

美国

生产商:

EpiCypher