HCN2 Antibody: ATTO 390-单抗-深圳欣博盛生物科技有限公司

首页产品中心单抗

HCN2 Antibody: ATTO 390

品牌：Stressmarq

官网链接

说明书

折扣/货期

货号：SMC-305D-A390

规格：100 µg

目录价：￥4939.2

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

HCN2 Antibody: ATTO 390

别名:

BCNG2 Antibody, HAC1 Antibody, brain cyclic nucleotide gated channel 2 Antibody, Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel Antibody

产品描述:

Mouse Anti-Rat HCN2 Monoclonal IgG1

反应种属:

Human | Mouse | Rat

宿主来源:

Mouse

实验应用:

WB | IHC | ICC/IF | IP | AM

靶标/特异性:

Detects ~95kDa. No cross-reactivity against HCN1.

同种型:

IgG1

推荐稀释度:

WB (1:1000), IHC (1:1000), ICC/IF (1:100); optimal dilutions for assays should be determined by the user.

免疫原:

Fusion protein amino acids 761-863 (cytoplasmic C-terminus) of rat HCN2

免疫原种属:

Rat

克隆性:

Monoclonal

克隆号:

S71

纯化方式:

Protein G Purified

偶联:

ATTO 390

产品浓度:

1 mg/ml

保存温度:

Conjugated antibodies should be stored according to the product label

运输温度:

Blue Ice or 4ºC

存储溶液:

PBS pH7.4, 50% glycerol, 0.09% sodium azide *Storage buffer may change when conjugated

产地:

加拿大

功能与背景:

Hyperpolarization-activated cyclic nucleotide-gated ion channel 2 (HCN2) is an integral membrane protein that helps establish and control the small voltage gradient across the plasma membrane of living cells by allowing the flow of ions down their electrochemical gradient (1). Ion channels are present in the membranes that surround all biological cells because their main function is to regulate the flow of ions across this membrane. Whereas some ion channels permit the passage of ions based on charge, others conduct based on a ionic species, such as sodium or potassium. Furthermore, in some ion channels, the passage is governed by a gate which is controlled by chemical or electrical signals, temperature, or mechanical forces. There are a few main classifications of gated ion channels. There are voltage- gated ion channels, ligand- gated, other gating systems and finally those that are classified differently, having more exotic characteristics. The first are voltage- gated ion channels which open and close in response to membrane potential. These are then separated into sodium, calcium, potassium, proton, transient receptor, and cyclic nucleotide-gated channels; each of which is responsible for a unique role. Ligand-gated ion channels are also known as ionotropic receptors, and they open in response to specific ligand molecules binding to the extracellular domain of the receptor protein. The other gated classifications include activation and inactivation by second messengers, inward-rectifier potassium channels, calcium-activated potassium channels, two-pore-domain potassium channels, light-gated channels, mechano-sensitive ion channels and cyclic nucleotide-gated channels. Finally, the other classifications are based on less normal characteristics such as two-pore channels, and transient receptor potential channels (2). Specifically, hyperpolarization-activated cation channels of the HCN gene family contribute to spontaneous rhythmic activity in both the heart and brain (3).

Accession #:

NP_446136.1