深圳欣博盛生物科技有限公司

HDDC3 Antibody / HD domain-containing protein 3

HDDC3 antibody detects HD domain-containing protein 3, a mitochondrial enzyme involved in NAD metabolism and stress-induced apoptosis regulation. The UniProt recommended name is HD domain-containing protein 3 (HDDC3). Also known as mitochondrial stress response protein MESH1, this enzyme exhibits NADPH phosphatase activity and modulates cellular redox state during stress adaptation.

Functionally, HDDC3 antibody identifies a 246-amino-acid protein localized to the mitochondrial matrix and cytoplasm. HDDC3 hydrolyzes NADPH to NADP+, regulating redox balance and reactive oxygen species production. It serves as a mammalian homolog of bacterial stringent response hydrolases, linking metabolic control to cell survival and autophagy.

The HDDC3 gene is located on chromosome 9q21.12 and is widely expressed, with highest levels in liver, kidney, and brain. Under oxidative or nutrient stress, HDDC3 modulates mitochondrial function, suppresses excessive NADPH accumulation, and contributes to redox homeostasis.

Pathologically, dysregulation of HDDC3 affects metabolic stress responses and apoptosis. Loss of function sensitizes cells to oxidative damage, while overexpression has been associated with tumor progression and altered NADPH signaling. Research using HDDC3 antibody supports studies in metabolism, mitochondrial dynamics, and cell death pathways.

HDDC3 antibody is validated for western blotting, immunofluorescence, and immunohistochemistry to detect NADPH-regulating enzymes. NSJ Bioreagents provides HDDC3 antibody reagents optimized for studies in mitochondrial metabolism, apoptosis, and redox biology.

Structurally, HD domain-containing protein 3 contains a conserved metal-dependent hydrolase domain that coordinates divalent cations for catalysis. This antibody enables analysis of HDDC3's enzymatic role in maintaining redox equilibrium and mitochondrial resilience.

Human, Mouse

Rabbit

WB, ELISA

Rabbit IgG

E.coli-derived human HDDC3 recombinant protein (Position: K25-I179) was used as the immunogen for the HDDC3 antibody.

Polyclonal (rabbit origin)

Immunogen affinity purified

After reconstitution, the HDDC3 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Lyophilized

Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml

美国