深圳欣博盛生物科技有限公司

POLDIP2 Antibody / Polymerase delta-interacting protein 2

POLDIP2 antibody detects Polymerase delta-interacting protein 2, a multifunctional protein that regulates DNA replication, repair, and mitochondrial function. The UniProt recommended name is Polymerase delta-interacting protein 2 (POLDIP2). This adaptor protein enhances the activity of DNA polymerase delta and coordinates cellular redox balance, cytoskeletal organization, and oxidative stress responses.

Functionally, POLDIP2 antibody identifies a 368-amino-acid protein localized to the nucleus, cytoplasm, and mitochondria. POLDIP2 binds to DNA polymerase delta subunit p50, stimulating processive DNA synthesis. It also interacts with NADPH oxidase 4 (NOX4), promoting the production of reactive oxygen species for signaling and host defense. In mitochondria, POLDIP2 influences respiratory complex stability and oxidative phosphorylation efficiency.

The POLDIP2 gene is located on chromosome 17q11.2 and is broadly expressed in metabolically active tissues, including heart, liver, and brain. Its expression is induced by stress signals and growth factors, integrating DNA repair, redox signaling, and metabolic regulation.

Pathologically, altered POLDIP2 expression has been linked to vascular remodeling, fibrosis, cancer, and neurodegenerative disorders. Overexpression promotes proliferation and migration in vascular smooth muscle cells, while deficiency impairs mitochondrial respiration and DNA replication fidelity. Research using POLDIP2 antibody supports studies in DNA metabolism, oxidative stress, and mitochondrial biology.

POLDIP2 antibody is validated for western blotting, immunofluorescence, and immunohistochemistry to detect replication-associated and redox-regulating proteins. NSJ Bioreagents provides POLDIP2 antibody reagents optimized for research in DNA repair, metabolism, and redox signaling.

Structurally, Polymerase delta-interacting protein 2 contains an N-terminal mitochondrial targeting sequence and a YccV-like domain involved in protein-protein interactions. This antibody facilitates investigation of POLDIP2's role in coordinating nuclear and mitochondrial stress responses.

Human, Mouse, Rat

Rabbit

ELISA, FACS, IP, IF, ICC, WB

Rabbit IgG

E.coli-derived human POLDIP2 recombinant protein (Position: Q81-Q324) was used as the immunogen for the POLDIP2 antibody.

Polyclonal (rabbit origin)

Immunogen affinity purified

After reconstitution, the POLDIP2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Lyophilized

Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml

美国