HES1 (human) (rec.) (His)-其他重组蛋白-深圳欣博盛生物科技有限公司

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HES1 (human) (rec.) (His)

品牌：Adipogen

官网链接

说明书

折扣/货期

货号：AG-40A-0180-C010	规格：10 ug	目录价：￥3480
货号：AG-40A-0180-C050	规格：50 ug	目录价：￥8280

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

HES1 (human) (rec.) (His)

别名:

Hairy and Enhancer of Split 1; Transcription Factor HES-1; Class B Basic Helix-loop-helix Protein 39; bHLHb39; Hairy Homolog; Hairy-like Protein; HRY; hHL

产品描述:

bHLH proteins are essential for neurogenesis, myogenesis, hematopoiesis and sex determination. HES1 (Hairy and Enhancer of Split 1) is a basic Helix-Loop-Helix (bHLH) transcriptional repressor regulated by the Notch pathway and expressed in various tissues. HES1 is well known in development of different tissues, particularly endoderm derived endocrine organs like pancreas and neuroendocrine cells of lung. HES1 controls normal development by regulating proliferation and differentiation and so cell fate. Notch signaling plays both oncogenic and tumor suppressor roles depending on cell type. In contrast to T cell acute lymphoblastic leukemia (ALL), where Notch activation promotes leukemogenesis, induction of Notch signaling in B cell ALL (B-ALL) leads to growth arrest and apoptosis. The Notch target HES1 is sufficient to reproduce this tumor suppressor phenotype in B-ALL by interacting and activating PARP-1 and regulating proapoptotic signals.

宿主来源:

E. coli

保存温度:

+4°C

运输温度:

预期分子量:

~35kDa (SDS-PAGE)

产品形式:

liquid

存储溶液:

Liquid. 0.2µm-filtered solution in 55mM TRIS-Cl, pH 8.2, containing 150mM NaCl.

产地: