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折扣/货期| 货号：AG-40A-0188Y-C010 | 规格：10 ug | 目录价：￥2400 |
| 货号：AG-40A-0188Y-C050 | 规格：50 ug | 目录价：￥5640 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
Progranulin (human) (rec.) (untagged)
别名:
Proepithelin; PEPI; PC Cell-derived Growth Factor
产品描述:
Progranulin (PGRN) is a widely expressed pluripotent growth factor which plays a role in processes such as development, wound repair and inflammation by activating signaling cascades that control cell cycle progression and cell motility. Its function in the central nervous system is of interest, as mutations in the PGRN gene were found in cases of frontotemporal degeneration (FTLD). In addition, PGRN has also been linked to tumorigenesis. Progranulin is a biomarker for FTLD, other types of Alzheimer‘s Disease (AD) and potentially for MCI (Mild Cognitive Impairment). Additionally, PGRN is described as a new ligand of TNF receptors and a potential therapeutic against inflammatory disease like arthritis. EphA2, a member of the large family of Ephrin receptor tyrosine kinases, is also a functional signaling receptor for progranulin as reported recently.
宿主来源:
HEK 293 cells
产品浓度:
After reconstitution:for 10µg size: 0.1mg/mlfor 50µg size: 1 mg/ml
保存温度:
+4°C
运输温度:
BI
预期分子量:
~74kDa (glycosylated protein by SDS-PAGE)
产品形式:
solid
存储溶液:
Lyophilized. Contains PBS.
产地:
瑞士
纯度:
>98% (SDS-PAGE)
生物活性:
Activates phospho-ERK1/2 in neuronal mouse P19 cells. Regulates food intake and body weight (see reference 1).
内毒素水平:
<0.01EU/µg purified protein (LAL test; Lonza).
促销活动
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