HES5 Antibody / BHLHB38-单抗-深圳欣博盛生物科技有限公司

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HES5 Antibody / BHLHB38

品牌：NSJ Bio

官网链接

说明书

折扣/货期

货号：V5758SAF-100UG

规格：100 ug

目录价：￥6652.1

产品详情

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产品名称:

HES5 Antibody / BHLHB38

产品描述:

The Drosophila Hairy and Enhancer of split genes encode basic helix-loop-helix (bHLH) transcriptional repressors that function in the Notch signaling pathway and control segmentation and neural development during embryogenesis. The mammalian homologues of Drosophila Hairy and Enhancer of split are the HES gene family members, HES1-6, which also encode bHLH transcriptional repressors that regulate myogenesis and neurogenesis. The HES family members form a complex with TLE, the mammalian homologue of Groucho, and this interaction is mediated by the carboxy terminal WRPW motif of the HES proteins. The HES/TLE complex functions by directly binding to DNA, instead of interfering with activator proteins. Most HES family members, including HES1 and HES5, preferentially bind to the N box (CACNAG) as opposed to the E box (CANNTG). HES2 binds to both N and E box sites, while HES6 does not bind DNA. Rather, HES6 inhibits HES1 activity, thereby promoting transcription. HES1 and HES2 are expressed in a variety of adult and embryonic tissues. HES3 is expressed exclusively in cerebellar Purkinje cells, and HES5 is found solely in the nervous system. HES6 is produced in brain as well as in the limb buds of developing embryos.

反应种属:

Human

宿主来源:

Mouse

实验应用:

IHC-P

同种型:

Mouse IgG2, kappa

免疫原:

A recombinant partial protein from human HES5 protein was used as the immunogen for the HES5 antibody.

克隆性:

Monoclonal (mouse origin)