HIF1 alpha antibody-多抗-深圳欣博盛生物科技有限公司

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HIF1 alpha antibody

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品牌：GeneTex

官网链接

说明书

折扣/货期

货号：GTX30647

规格：100μl

目录价：￥7200

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

HIF1 alpha antibody

别名:

hypoxia inducible factor 1, alpha subunit , AA959795 , HIF-1-alpha , HIF1-alpha , HIF1alpha , MOP1 , bHLHe78

反应种属:

Goat, Hamster, Human, Monkey, Mouse, Primate, Rabbit, Rat

宿主来源:

Rabbit

实验应用:

ChIP assay, FCM, ICC/IF, IHC-Fr, IHC-P, IP, WB

同种型:

IgG

免疫原:

A fusion protein including amino acids 530 - 825 of the mouse HIF-1 alpha protein [UniProt# Q61221].

克隆性:

Polyclonal

克隆号:

纯化方式:

Purified by antigen-affinity chromatography

偶联:

Unconjugated

产品浓度:

1 mg/ml (Please refer to the vial label for the specific concentration.)

保存温度:

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC. DO NOT FREEZE.

运输温度:

4°C

预期分子量:

产品形式:

Liquid

存储溶液:

PBS, 0.05% Sodium azide.

生产商:

GeneTex

功能与背景:

Functions as a master transcriptional regulator of the adaptive response to hypoxia. Under hypoxic conditions activates the transcription of over 40 genes, including, erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. Plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Binds to core DNA sequence 5'-[AG]CGTG-3' within the hypoxia response element (HRE) of target gene promoters. Activation requires recruitment of transcriptional coactivators such as CREBPB and EP300. Activity is enhanced by interaction with both, NCOA1 or NCOA2. Interaction with redox regulatory protein APEX seems to activate CTAD and potentiates activation by NCOA1 and CREBBP.

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