官网链接
折扣/货期| 货号：SMC-184D-PCP | 规格：100 µg | 目录价：￥4460.4 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
HIF1 alpha Antibody: PerCP
别名:
ARNT interacting protein Antibody, HIF1A Antibody, Hypoxia inducible factor 1 alpha Antibody, MOP1 Antibody, PASD8 Antibody
产品描述:
Mouse Anti-Mouse HIF1 alpha Monoclonal IgG1
反应种属:
Human | Mouse | Rat | Bovine
宿主来源:
Mouse
实验应用:
WB | IHC | ICC/IF | ELISA
靶标/特异性:
Detects ~116kDa. Specific for HIF1Alpha.
同种型:
IgG1
推荐稀释度:
WB (1:1000), IHC (1:100), ICC/IF (1:50); optimal dilutions for assays should be determined by the user.
免疫原:
Mouse recombinant fragment corresponding to amino acids 329-541
免疫原种属:
Mouse
克隆性:
Monoclonal
克隆号:
ESEE122
纯化方式:
Protein G Purified
偶联:
PerCP
产品浓度:
1 mg/ml
保存温度:
Conjugated antibodies should be stored according to the product label
运输温度:
Blue Ice or 4ºC
存储溶液:
PBS pH7.4, 50% glycerol, 0.09% sodium azide *Storage buffer may change when conjugated
产地:
加拿大
功能与背景:
Hypoxia-inducible factor 1 (HIF1) is a heterodimeric transcription factor that plays a critical role in the cellular response of hypoxia (1). The HIF1 complex consists of two subunits, HIF1-Alpha and HIF1-Beta, which are basic helix-loop-helix proteins of the PAS family (2). HIF1 regulates the transcription of a broad range of genes that facilitate responses to the hypoxic environment, including genes regulating angiogenesis, erythropoiesis, cell cycle, metabolism and apoptosis. The widely expressed HIF-1α is typically degraded rapidly in normoxic cells by the ubiquitin/proteasomal pathway. Under normoxic conditions, HIF-1α is proline hydroxylated leading to a conformational change that promotes binding to the von Hippel Lindau protein (VLH) E3 ligase complex; ubiquitination and proteasomal degradation follows (3, 4). Both hypoxic conditions and chemical hydroxylase inhibitors (such as desferrioxamine and cobalt) inhibit HIF-1α degradation and lead to its stabilization. In addition, HIF-1α can be induced in an oxygen-independent manner by various cytokines through the PI3K-AKT-mTOR pathway (5-7).
Accession #:
NP_034561.2
您可能感兴趣的产品
Anti-H-Ficolin (human)
货号：RIG 334-01B-015
Anti-Complement factor H (human, ß1H-globulin)
货号：GAU 020-03B-015
Anti-Complement component C3a/C3a(desArg)/C3 (human)
货号：GAU 017-01B-015
Anti-Complement factor D (human)
货号：GAU 008-01B-015
Anti-Complement component C5b-9
货号：DIA 011-01B-015
Anti-Fibronectin (bovine, human)
货号：CSI 005-32-04
Anti-Vitronectin (bovine, sheep)
货号：CSI 004-27-04
Anti-Vitronectin (human, dog, cat, goat, horse, bovine)
货号：CSI 003-23-04
促销活动
精品推荐
复制QQ号成功，请打开QQ后添加好友进行咨询