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折扣/货期| 货号：GTX30109 | 规格：100μl | 目录价：￥8200 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
HIF1 beta antibody
别名:
aryl hydrocarbon receptor nuclear translocator , HIF-1-beta , HIF-1beta , HIF1-beta , HIF1B , HIF1BETA , TANGO , bHLHe2
反应种属:
Bovine, Ferret, Human, Mouse, Rat, Sheep
宿主来源:
Rabbit
实验应用:
ChIP assay, Gel supershift assays, ICC/IF, IHC-P, IP, WB
靶标/特异性:
This antibody is specific to HIF1 beta / ARNT. The cross-reactivity of ARNT2 is not determined.
同种型:
IgG
免疫原:
Fusion protein to human HIF-1 beta containing amino acids 496-789. [UniProt# P27540]
克隆性:
Polyclonal
克隆号:
纯化方式:
Unpurified
偶联:
Unconjugated
产品浓度:
保存温度:
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
运输温度:
4°C
产品形式:
Liquid
存储溶液:
Serum, 0.02% Sodium azide.
生产商:
GeneTex
功能与背景:
The aryl hydrocarbon (Ah) receptor is involved in the induction of several enzymes that participate in xenobiotic metabolism. The ligand-free, cytosolic form of the Ah receptor is complexed to heat shock protein 90. Binding of ligand, which includes dioxin and polycyclic aromatic hydrocarbons, results in translocation of the ligand-binding subunit only to the nucleus. Induction of enzymes involved in xenobiotic metabolism occurs through binding of the ligand-bound Ah receptor to xenobiotic responsive elements in the promoters of genes for these enzymes. This gene encodes a protein that forms a complex with the ligand-bound Ah receptor, and is required for receptor function. The encoded protein has also been identified as the beta subunit of a heterodimeric transcription factor, hypoxia-inducible factor 1 (HIF1). A t(1;12)(q21;p13) translocation, which results in a TEL-ARNT fusion protein, is associated with acute myeloblastic leukemia. Three alternatively spliced variants encoding different isoforms have been described for this gene. [provided by RefSeq]
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