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折扣/货期| 货号：CHI-RR-300HMGB1-C025 | 规格：25 ug | 目录价：￥4060 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
HMGB1 (rat) (rec.) (His)
别名:
High Mobility Group Protein B1
产品描述:
HMGB1 was originally discovered as an essential DNA-binding protein for regulating p53, NF-kappaB and other important proteins. It is secreted from activated dentric cells, macrophage and nectrotic cells, and acts as a ligand for RAGE, TLR-2 and TLR-4 expressed on surrounding cells. As a result, HMGB1 activates Rac, CDC42 and NF-kappaB inducing localized innate immunity of damaged tissue, tissue regeneration by recruitment of stem cells and hemostasis by induction of tissue factor expression. HMGB1 is also causative agent of various diseases as it causes localized inflammation such as arteriosclerosis, chronic rheumatoid arthritis and nephritis.
宿主来源:
E. coli
保存温度:
+4°C
运输温度:
BI
预期分子量:
~25-35kDa
产品形式:
solid
存储溶液:
Lyophilized from a concentrated sterile solution containing 50mM Tris-Hcl buffer (pH 8.0) and 100mM NaCl.
产地:
瑞士
纯度:
>90% (SDS-PAGE)
内毒素水平:
<1EU/mg protein (LAL test; Lonza).
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