Parkin (E3 Ligase) (human) (rec.) (His)-其他重组蛋白-深圳欣博盛生物科技有限公司

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Parkin (E3 Ligase) (human) (rec.) (His)

品牌：Adipogen

官网链接

说明书

折扣/货期

货号：SBB-CE0055-C050

规格：50 ug

目录价：￥6496

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

Parkin (E3 Ligase) (human) (rec.) (His)

别名:

PARK2; E3 Ubiquitin-protein Ligase Parkin; Parkin RBR E3 Ubiquitin-protein Ligase; Parkinson Juvenile Disease Protein 2; Parkinson Disease Protein 2; PRKN

产品描述:

Parkin (Parkinson juvenile disease protein 2) is a ~52kDa E3 Ligase enzyme protein, encoded by the PARK2 gene. It plays an important role in the ubiquitin-proteasome system and acts as a regulator of protein breakdown. Parkin is located in the cytoplasma until a sustained depolarization occurs after which it is translocated to the mitochondrial membrane and induces the degradation of various membrane proteins. Parkin mutation leads to the accumulation of missfolded, aggregated proteins and degenerated mitochondria. The role of these changes in the pathomechanism of neurodegenerative diseases is well-known. Parkin mutation is responsible for about 50% of familial cases and for 10 to 20% of youth cases. Present views are that the improper regulation of protein aggregation and a dysfunction of the ubiquitin-proteasome system may be the common pathway of sporadic and hereditary Parkinson’s disease. In vitro, Parkin can be activated by treatment with recombinant PINK1, or addition of low concentrations of pS65-phosphoubiquitin. Parkin has been reported to generate poly-Ubiquitin chains in K6, K11, K48, and K63 linkages both in vitro and in vivo.

宿主来源:

Sf9 cells

产品浓度:

Lot dependent.

保存温度:

-80°C

运输温度:

Dry Ice

预期分子量:

~52kDa

产品形式:

liquid