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折扣/货期| 货号：GTX29547 | 规格：200μl | 目录价：￥6300 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
hnRNP M1-M4 antibody [1D8]
反应种属:
Bovine, Human, Mouse, Pig, Rabbit, Rat
宿主来源:
Mouse
实验应用:
ICC/IF, IHC-Fr, IHC-P, IP, WB
靶标/特异性:
This antibody is specific for all four M proteins of hnRNP (M1, M2, M3 and M4).
同种型:
IgG1
免疫原:
M19 fusion protein containing full-length human protein. [UniProt# P52272]
克隆性:
Monoclonal
克隆号:
1D8
纯化方式:
Unpurified
偶联:
Unconjugated
产品浓度:
保存温度:
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
运输温度:
4°C
产品形式:
Liquid
存储溶液:
Ascites, 0.1% Sodium azide.
生产商:
GeneTex
功能与背景:
Proteins that directly bind to nascent RNA polymerase II transcripts, the heterogenous nuclear ribonucleoproteins (hnRNPs), play an important role in both transcript-specific packaging and alternative splicing of pre-mRNAs. A group of abundant hnRNPs, the M1-M4 proteins, appear as a cluster of four proteins. The M proteins are pre-mRNA binding proteins in vivo, and they bind avidly to poly (G) and poly (U) RNA homopolymers in vitro. M proteins are members of the ribonucleoprotein consensus sequence family of RNA-binding proteins with greatest similarity to a hypothetical RNA-binding protein from Saccharomyces cerevisiae. The M proteins also possess an unusual hexapeptide-repeat region rich in methionine and arginine residues (MR repeat motif) that resembles a repeat in the 64kDa subunit of cleavage stimulation factor, which is involved in 3'-end maturation of pre-mRNAs. Proteins immunologically related to M exist in divergent eukaryotes ranging from human to yeast.
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