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折扣/货期| 货号：SMC-234D | 规格：100 µg | 目录价：￥4246.2 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
HO-1 (Rat) Antibody
别名:
HSP32 Antibody, HMOX1 Antibody, Heme oxygenase 1 Antibody, HO Antibody, HO1 Antibody, , 32 kD antibody, bK286B10 antibody, D8Wsu38e antibody, heat shock protein 32 kD antibody, heat shock protein 32kD antibody, Heat shock protein antibody, Heme oxygenase (decycling) 1 antibody, Heme oxygenase 1 antibody, Hemox antibody, HMOX 1 antibody, Hmox antibody, Hmox1 antibody, HMOX1_HUMAN antibody, HO 1 antibody, HO antibody, HO-1 antibody, HO1 antibody, Hsp32 antibody
产品描述:
Mouse Anti-Rat HO-1 Monoclonal IgG1 Kappa
反应种属:
Human | Mouse | Rat
宿主来源:
Mouse
实验应用:
WB | ICC/IF
靶标/特异性:
Detects ~32kDa. Does not cross-react with HO-2.
同种型:
IgG1 Kappa
推荐稀释度:
WB (1:1000), ICC/IF (1:100); optimal dilutions for assays should be determined by the user.
免疫原:
His-tagged Rat HO-1
免疫原种属:
Rat
克隆性:
Monoclonal
克隆号:
6B8-2F2
纯化方式:
Protein G Purified
偶联:
Unconjugated
产品浓度:
1 mg/ml
保存温度:
-20ºC
运输温度:
Blue Ice or 4ºC
存储溶液:
PBS, 50% glycerol, 0.1% sodium azide *Storage buffer may change when conjugated
产地:
加拿大
功能与背景:
Heme-oxygenase is a ubiquitous enzyme that catalyzes the initial and rate-limiting steps in heme catabolism yielding equimolar amounts of biliverdin, iron and carbon monoxide. Biliverdin is subsequently converted to bilirubin and the free iron is sequestered to ferritin (1). These products have important physiological effects as carbon monoxide is a potent vasodilator; biliverdin and bilirubin are potent antioxidants; and the free iron increases oxidative stress and regulates the expression of many mRNAs (2). There are three isoforms of heme-oxygenase, HO-1, HO-2 and HO-3; however HO-1 and HO-2 are the major isoforms as they both have been identified in mammals (3). HO-1, also known as heat shock protein 32, is an inducible isoform activated by most oxidative stress inducers, cytokines, inflammatory agents and heat shock. HO-2 is a constitutive isoform which is expressed under homeostatic conditions. HO-1 is also considered to be a cytoprotective factor in that free heme is highly reactive and cytotoxic, and secondly, carbon monoxide is a mediator inhibiting the inflammatory process and bilirubin is a scavenger for reactive oxygen, both of which are the end products of heme catalyzation (4). It has also been shown that HO-1 deficiency may cause reduced stress defense, a pro-inflammatory tendency (5), susceptibility to atherosclerotic lesion formation (6), endothelial cell injury, and growth retardation (7). Up-regulation of HO-1 is therefore said to be one of the major defense mechanisms of oxidative stress (4).
Accession #:
NP_036712.1
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