Human Fas protein, His and MBP tag-其他重组蛋白-深圳欣博盛生物科技有限公司

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Human Fas protein, His and MBP tag

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品牌：GeneTex

官网链接

说明书

折扣/货期

货号：GTX00080-pro

规格：10μg

目录价：￥4100

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

Human Fas protein, His and MBP tag

别名:

Fas cell surface death receptor , ALPS1A , APO-1 , APT1 , CD95 , FAS1 , FASTM , TNFRSF6

实验应用:

Functional Assay

克隆号:

偶联:

Unconjugated

产品浓度:

表达系统:

E. coli

保存温度:

For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, store at -20ºC or below. After reconstitution, keep as concentrated solution. Avoid freeze-thaw cycles.

运输温度:

4°C

产品形式:

Lyophilized powder

存储溶液:

Reconstitute with 20mM Tris and 150mM NaCl to 0.1-1.0mg/ml. Do not vortex. Lyophilized from 20mM Tris, 150mM NaCl, 1mM EDTA, 1mM DTT, 0.01% SKL, 5% Trehalose, ProClin 300.

生产商:

GeneTex

功能与背景:

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains a death domain. It has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. The interaction of this receptor with its ligand allows the formation of a death-inducing signaling complex that includes Fas-associated death domain protein (FADD), caspase 8, and caspase 10. The autoproteolytic processing of the caspases in the complex triggers a downstream caspase cascade, and leads to apoptosis. This receptor has been also shown to activate NF-kappaB, MAPK3/ERK1, and MAPK8/JNK, and is found to be involved in transducing the proliferating signals in normal diploid fibroblast and T cells. Several alternatively spliced transcript variants have been described, some of which are candidates for nonsense-mediated mRNA decay (NMD). The isoforms lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full length isoform. [provided by RefSeq, Mar 2011]

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