Human FKBP4 protein, His tag (active)-其他重组蛋白-深圳欣博盛生物科技有限公司

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Human FKBP4 protein, His tag (active)

品牌：GeneTex

官网链接

说明书

折扣/货期

货号：GTX66995-pro

规格：100μg

目录价：￥3500

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

Human FKBP4 protein, His tag (active)

别名:

FKBP prolyl isomerase 4 , FKBP51 , FKBP52 , FKBP59 , HBI , Hsp56 , PPIase , p52

实验应用:

Functional Assay

克隆号:

偶联:

Unconjugated

产品浓度:

1 mg/ml (Please refer to the vial label for the specific concentration.)

表达系统:

E. coli

保存温度:

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

运输温度:

dry ice

产品形式:

Liquid

存储溶液:

20mM Tris-HCl, 10% Glycerol, no preservatives.

生产商:

GeneTex

功能与背景:

The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It has high structural and functional similarity to FK506-binding protein 1A (FKBP1A), but unlike FKBP1A, this protein does not have immunosuppressant activity when complexed with FK506. It interacts with interferon regulatory factor-4 and plays an important role in immunoregulatory gene expression in B and T lymphocytes. This encoded protein is known to associate with phytanoyl-CoA alpha-hydroxylase. It can also associate with two heat shock proteins (hsp90 and hsp70) and thus may play a role in the intracellular trafficking of hetero-oligomeric forms of the steroid hormone receptors. This protein correlates strongly with adeno-associated virus type 2 vectors (AAV) resulting in a significant increase in AAV-mediated transgene expression in human cell lines. Thus this encoded protein is thought to have important implications for the optimal use of AAV vectors in human gene therapy. The human genome contains several non-transcribed pseudogenes similar to this gene. [provided by RefSeq, Sep 2008]

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