Human HSBP1 protein-其他重组蛋白-深圳欣博盛生物科技有限公司

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Human HSBP1 protein

品牌：GeneTex

官网链接

说明书

折扣/货期

货号：GTX67479-pro

规格：100μg

目录价：￥3500

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

Human HSBP1 protein

别名:

heat shock factor binding protein 1 , NPC-A-13

克隆号:

偶联:

Unconjugated

产品浓度:

1 mg/ml (Please refer to the vial label for the specific concentration.)

表达系统:

E. coli

保存温度:

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

运输温度:

dry ice

产品形式:

Liquid

存储溶液:

20mM Tris-HCl, 50mM NaCl, 20% Glycerol, no preservatives.

生产商:

GeneTex

功能与背景:

The heat-shock response is elicited by exposure of cells to thermal and chemical stress and through the activation of HSFs (heat shock factors) results in the elevated expression of heat-shock induced genes. Heat shock factor binding protein 1 (HSBP1), is a 76-amino-acid protein that binds to heat shock factor 1(HSF1), which is a transcription factor involved in the HS response. During HS response, HSF1 undergoes conformational transition from an inert non-DNA-binding monomer to active functional trimers. HSBP1 is nuclear-localized and interacts with the active trimeric state of HSF1 to negatively regulate HSF1 DNA-binding activity. Overexpression of HSBP1 in mammalian cells represses the transactivation activity of HSF1. When overexpressed in C.elegans HSBP1 has severe effects on survival of the animals after thermal and chemical stress consistent with a role of HSBP1 as a negative regulator of heat shock response. [provided by RefSeq, Jul 2008]

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