Human Recombinant Alpha Synuclein G51D Mutant PFFs-其他重组蛋白-深圳欣博盛生物科技有限公司

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Human Recombinant Alpha Synuclein G51D Mutant PFFs

品牌：Stressmarq

官网链接

说明书

折扣/货期

货号：SPR-541B

规格：100 µg

目录价：￥6363

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

Human Recombinant Alpha Synuclein G51D Mutant PFFs

别名:

G51D α-synuclein, Alpha-synuclein G51D, α-Synuclein G51D, G51D α-synuclein, α-Synuclein p.Gly51Asp, α-Synuclein Gly51Asp, Human alpha-synuclein G51D, G51D mutant alpha-synuclein, SNCA Gly51Asp, G51D α-synuclein PFF, G51D alpha-synuclein PFF, Alpha-synuclein G51D PFF, α-Synuclein G51D PFF, G51D α-synuclein pre-formed fibrils, G51D α-synuclein preformed fibrils, Alpha-synuclein G51D pre-formed fibrils, Alpha-synuclein G51D preformed fibrils, G51D mutant α-synuclein fibrils, G51D α-synuclein fibrils, Recombinant G51D α-synuclein PFFs, G51D α-synuclein PFFs

实验应用:

WB | SDS-PAGE | In vivo assay | In vitro assay

纯化方式:

Ion-Exchange Purified

偶联:

No tag

产品浓度:

2 mg/mL

表达系统:

E. coli

保存温度:

-80ºC

运输温度:

Dry Ice. Shipping note: Product will be shipped separately from other products purchased in the same order.

预期分子量:

14.52 kDa

存储溶液:

PBS pH 7.4

产地:

加拿大

生产商:

Stressmarq

功能与背景:

The G51D mutation in SNCA, which substitutes aspartic acid for glycine at residue 51 of alpha-synuclein, is associated with an early-onset neurodegenerative syndrome that combines clinical and neuropathological features of Parkinson’s disease (PD) and multiple system atrophy (MSA). G51D-associated disease is characterized by widespread neuronal alpha-synuclein pathology together with oligodendroglial inclusions resembling those observed in MSA. Cryo-electron microscopy further demonstrated that alpha synuclein with the G51D mutation forms a structurally distinct fibril strain capable of cross-seeding wild-type alpha-synuclein, supporting a role for conformational strain selection and templated propagation in disease. Consistent with this strain model, patient-derived G51D aggregates produced a restricted, slowly propagating synucleinopathy in transgenic mice and displayed biochemical and seeding properties distinct from MSA-derived aggregates. StressMarq’s Human Recombinant Alpha Synuclein G51D Mutant Pre-Formed Fibrils do not bind Thioflavin T as readily as ones formed using wild-type monomers, indicating a distinct fibril structure.

纯度:

>95%

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