Human Thymidylate synthase protein, His tag-其他重组蛋白-深圳欣博盛生物科技有限公司

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Human Thymidylate synthase protein, His tag

品牌：GeneTex

官网链接

说明书

折扣/货期

货号：GTX67911-pro

规格：100μg

目录价：￥4000

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

Human Thymidylate synthase protein, His tag

别名:

thymidylate synthetase , HST422 , TMS , TS

克隆号:

偶联:

Unconjugated

产品浓度:

1 mg/ml (Please refer to the vial label for the specific concentration.)

表达系统:

E. coli

保存温度:

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

运输温度:

dry ice

产品形式:

Liquid

存储溶液:

20mM Tris-HCl, 100mM NaCl, 10% Glycerol, 1mM DTT, no preservatives.

生产商:

GeneTex

功能与背景:

Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using, 10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs. Expression of this gene and that of a naturally occurring antisense transcript, mitochondrial enolase superfamily member 1 (GeneID:55556), vary inversely when cell-growth progresses from late-log to plateau phase. Polymorphisms in this gene may be associated with etiology of neoplasia, including breast cancer, and response to chemotherapy. [provided by RefSeq, Aug 2017]

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