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折扣/货期| 货号：40654-10 mg | 规格：10 mg | 目录价：￥4355 |
| 货号：40654-100 mg | 规格：100 mg | 目录价：￥13708 |
| 货号：40654-5 mg | 规格：5 mg | 目录价：￥2291 |
| 货号：40654-50 mg | 规格：50 mg | 目录价：￥8013 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
IACS-13909
产品描述:
An allosteric inhibitor of SHP-2 (IC50 = 11 nM); binds wild-type SHP-2 and SHP-2E76K (Kds = 49 and 211 nM, respectively); decreases the levels of phosphorylated ERK in KYSE-520 cells (IC50 = 47 nM) but also inhibits hERG channels (IC50 = 180 nM in a whole-cell patch-clamp assay using CHO cells); decreases tumor volume without affecting body weight in an EGFR-overexpressing KYSE-520 esophageal cancer mouse xenograft model at 70 mg/kg per day; induces sustained reduction in tumor volume after dosing cessation in a NSCLC mouse xenograft model using H1975 cells expressing drug-resistant EGFRL858R/T790M/C797S at 70 mg/kg per day
保存温度:
-20
运输温度:
-20
预期分子量:
377.27066
产品形式:
A solid
纯度:
≥98%
CAS号:
2160546-07-4
分子式:
C17H18Cl2N6
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