ICAM-1 Antibody / CD54-单抗-深圳欣博盛生物科技有限公司

首页产品中心单抗

ICAM-1 Antibody / CD54

品牌：NSJ Bio

官网链接

说明书

折扣/货期

货号：V2604-100UG	规格：100 ug	目录价：￥6652.1
货号：V2604-20UG	规格：20 ug	目录价：￥3082.1

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

ICAM-1 Antibody / CD54

产品描述:

Recognizes an 85-115kDa protein (variation with cell type), identified as intercellular adhesion molecule (ICAM-1) (Workshop IV). It has 7 potential N-linked glycosylation sites. ICAM-1 is a single chain glycoprotein of Ig supergene family, present on unstimulated endothelial cells (EC) and on a variety of other cell types including activated fibroblasts, EC, macrophages, and lymphocytes. ICAM-1 mediates cell adhesion by binding to integrins CD11a/CD18 (leukocyte adhesion molecule, LFA-1) and to CD11b/CD18 (Mac-1). This interaction enhances antigen-specific T-cell activation. ICAM-1 also binds to CD43 and to Plasmodium falciparum infected RBCs. W-CAM-1 mAb blocks aggregation of cell lines mediated by the ICAM-1 and blocks homotypic binding of purified populations of activated T- and B-lymphocytes and also aggregation of mixed T- and B-cell blasts. It inhibits T-cell adhesion to normal human endothelial cells. Activation induced by cell-cell contact (mixed lymphocyte reaction, T-cell mediated B-cell activation) is significantly inhibited. This mAb blocks elements of both effector arms of immune system (cytotoxic cell function and Ig production).

反应种属:

Human. Other species not known.

宿主来源:

Mouse

实验应用:

FACS, IHC-P, Functional Testing

同种型:

Mouse IgG2b, kappa

免疫原:

Raji Burkitt lymphoma cells were used as the immunogen for the ICAM-1 antibody.

克隆性:

Monoclonal (mouse origin)