IKB alpha antibody-多抗-深圳欣博盛生物科技有限公司

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IKB alpha antibody

品牌：GeneTex

官网链接

说明书

折扣/货期

货号：GTX27545

规格：50μl

目录价：￥5300

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

IKB alpha antibody

别名:

NFKB inhibitor alpha , EDAID2 , IKBA , MAD-3 , NFKBI

反应种属:

Human, Mouse, Rat

宿主来源:

Rabbit

实验应用:

ELISA, EMSA, IHC, WB

同种型:

IgG

免疫原:

Synthetic IkBa peptide corresponding to a region near the C-terminus of the human protein.

克隆性:

Polyclonal

克隆号:

偶联:

Unconjugated

产品浓度:

80 mg/ml (Please refer to the vial label for the specific concentration.)

保存温度:

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

运输温度:

4°C

产品形式:

Liquid

存储溶液:

20mM Potassium Phosphate, 150mM NaCl, 0.1% Sodium azide.

生产商:

GeneTex

功能与背景:

Three major forms of IkB-like molecules have been identified and each is characterized by multiple copies of ankyrin repeats. IkB-alpha and IkB-beta appear to be the major regulatory forms of IkB in most cells. These proteins interact with p65 or c-Rel containing forms of NFkB and block nuclear import by masking the nuclear localization sequences of NFkB. The activation of NFkB involves the inducible phosphorylation and subsequent degradation of IkB. Immunoblotting easily detects the hyper-phosphorylated forms of IkB-alpha, but not phosphorylated IkB-beta. Interestingly, IkB-alpha and IkB-beta mediate different NFkB responses. IkB-alpha appears to control more transient activation of NFkB in response to an inducer, while IkB-beta controls a persistent response. Bcl-3 interacts with p50 and p52 containing forms of NFkB, but rather than being an inhibitor it appears to function to stimulate transcription. The degradation of IkB is confirmed by immunoblotting.

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