IKZF1 Antibody / IKAROS-单抗-深圳欣博盛生物科技有限公司

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IKZF1 Antibody / IKAROS

品牌：NSJ Bio

官网链接

说明书

折扣/货期

货号：RQ7622

规格：100 ug

目录价：￥6488

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

IKZF1 Antibody / IKAROS

产品描述:

DNA-binding protein Ikaros is a protein that in humans is encoded by the IKZF1 gene. This gene encodes a transcription factor that belongs to the family of zinc-finger DNA-binding proteins associated with chromatin remodeling. The expression of this protein is restricted to the fetal and adult hemo-lymphopoietic system, and it functions as a regulator of lymphocyte differentiation. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. Most isoforms share a common C-terminal domain, which contains two zinc finger motifs that are required for hetero- or homo-dimerization, and for interactions with other proteins. The isoforms, however, differ in the number of N-terminal zinc finger motifs that bind DNA and in nuclear localization signal presence, resulting in members with and without DNA-binding properties. Only a few isoforms contain the requisite three or more N-terminal zinc motifs that confer high affinity binding to a specific core DNA sequence element in the promoters of target genes. The non-DNA-binding isoforms are largely found in the cytoplasm, and are thought to function as dominant-negative factors.

反应种属:

Human

宿主来源:

Mouse

实验应用:

同种型:

Mouse IgG1

免疫原:

Amino acids 428-459 (LKEEHRAYDLLRAASENSQDALRVVSTSGEQM) from the human protein were used as the immunogen for the IKZF1 antibody.

克隆性:

Monoclonal (mouse origin)

克隆号:

5F12H7

纯化方式:

Antigen affinity purified

保存温度:

After reconstitution, the IKZF1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

产品形式:

Antigen affinity purified

存储溶液:

0.5mg/ml if reconstituted with 0.2ml sterile DI water

产地:

美国

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