IL-18BP (mouse) (monomer):Fc (silent) InVivoKine™-Fc融合蛋白-深圳欣博盛生物科技有限公司

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IL-18BP (mouse) (monomer):Fc (silent) InVivoKine™

品牌：Adipogen

官网链接

说明书

折扣/货期

货号：AG-40B-0277-C050

规格：50 ug

目录价：￥4800

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

IL-18BP (mouse) (monomer):Fc (silent) InVivoKine™

别名:

Interleukin-18-binding Protein (mouse) (monomeric):Fc (LALA-PG) Knobs-into-Holes (human) (rec.); Interferon gamma-inducing Factor-binding Protein

产品描述:

IL-18, initially named interferon-gamma inducing factor (IGIF) is an IL-1 family member and a cytokine that links innate and adaptive immunity. Depending on the microenvironment and timing, IL-18 can either drive harmful inflammation or restore immune homeostasis. IL-18 is regulated i) by the inflammasome that converts the inactive pro-IL-18 to its active form IL-18; ii) by the cytokine it induces, the master cytokine IFN-gamma that triggers the expression of the inhibitor of IL-18, called IL-18 binding protein (IL-18BP). IL-18 binding protein (IL-18BP) is one of only four natural cytokine antagonists. IL-18BP has an exceptionally high affinity for IL-18 and its slow dissociation rate makes it an effective regulator of IL-18, essential for maintaining immune balance and influencing disease outcomes. The IL-18BP (mouse) (monomer):Fc (silent) InVivoKine™ is produced by using two different vectors, one encoding for the IL-18BP (mouse):Fc (LALA-PG) Knobs sequence (synthesizing a protein of 70kDa) and one encoding for the Fc (LALA-PG) Holes sequence (synthesizing a protein of 28kDa). Both vectors transfected into CHO cells produce both Fc molecules (Knobs-into-Holes technology; J.B. Ridgway, et al.; Protein Eng. 9, 617 (1996) required for dimerization of the Fc moieties and for secretion of the final protein IL-18BP (mouse) (monomer):Fc (silent) InVivoKine™. The LALA-PG mutations inhibit binding to FcgammaRs and C1q, while FcRn binding and Fc stability remain unaffected. InVivoKines™ are a new generation of recombinant fusion proteins for immunotherapeutic, preclinical, and translational in vivo research, developed and manufactured by AdipoGen Life Sciences.

宿主来源:

CHO cells. Produced using animal component-free medium.

靶标/特异性:

Binds to mouse IL-18. The Fc contains the mutations LALA-PG that abolish the interaction between the Fc and FcgammaRs and therefore Fc undesirable effects.

产品浓度:

After reconstitution: 1mg/ml

保存温度:

+4°C

运输温度:

预期分子量:

~70kDa and 28kDa (SDS-PAGE)

产品形式:

solid

存储溶液:

Lyophilized. Contains PBS.

产地: