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折扣/货期| 货号：AG-40B-0254-C050 | 规格：50 ug | 目录价：￥4800 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
IL-1Ra (mouse) (monomer):Fc (silent) InVivoKine™
别名:
Fc (LALA-PG)-KIH:Interleukin-1 Receptor Antagonist (mouse); IL-1Ra; Interleukin-1R Antagonist
产品描述:
IL-1 is a group of inflammatory cytokines, represented by interleukin-1alpha and interleukin-1beta. IL-1Ra is a cytokine initially isolated from macrophages. It shares 19% of homologous amino acids with IL1A and 30% of homologous amino acids with IL1B. IL-1Ra is abundant in the proximal digestive tract reproductive system, skin, bone marrow, and liver. IL-1Ra is the principal endogenous IL-1 antagonist. IL-1Ra is upregulated during host acute or chronic inflammatory responses. IL-1Ra plays diverse roles in anti-inflammatory and anti-tumor processes, either inhibiting tumor angiogenesis and proliferation or suppressing tumor migration and metastasis. The IL-1Ra (mouse) (monomer):Fc (silent) InVivoKine™ is produced by using two different vectors, one encoding for the Fc Knobs (LALA-PG) (human):IL-1Ra (mouse) sequence (synthesizing a protein of 50kDa) and one encoding for the Fc Holes (LALA-PG) sequence (synthesizing a protein of 30kDa). Both vectors transfected into HEK293 cells produce both Fc molecules (Knobs-into-Holes technology; J.B. Ridgway, et al.; Protein Eng. 9, 617 (1996)) required for dimerization and for secretion of the final protein IL-1Ra (mouse) (monomer):Fc (silent) InVivoKine™. This Fc-KIH format allows our mouse IL-1Ra protein to form a monomer that is the most active structure to bind and inhibit the IL-1 receptor. The LALA-PG mutations inhibit binding to FcgammaRs and C1q while FcRn binding and Fc stability remain unaffected. InVivoKines™ are a new generation of recombinant fusion proteins for immunotherapeutic, preclinical and translational in vivo research, developed and manufactured by AdipoGen Life Sciences.
宿主来源:
HEK 293 cells. Produced using animal component-free medium.
靶标/特异性:
Binds to mouse IL-1R1. Fc (LALA-PG)-KIH (human) does not bind to FcRs. The Fc contains the mutations LALA-PG that abolish the interaction between the Fc and FcgammaRs and therefore Fc undesirable effects.
产品浓度:
1mg/ml after reconstitution.
保存温度:
+4°C
运输温度:
BI
预期分子量:
~50kDa and 30 kDa (SDS-PAGE)
产品形式:
solid
存储溶液:
Lyophilized. Contains PBS
产地:
瑞士
纯度:
>95% (SDS-PAGE)
生物活性:
It inhibits the binding of IL-1alpha and IL-1beta to the receptor IL-1R.
内毒素水平:
<0.005 EU/µg purified protein (LAL test).
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