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折扣/货期| 货号：AG-40A-0053-C010 | 规格：10 ug | 目录价：￥1560 |
| 货号：AG-40A-0053-C050 | 规格：50 ug | 目录价：￥4680 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
IL-33 (mouse) (rec.) (His)
别名:
Interleukin-33; IL-1F11; NF-HEV
产品描述:
Interleukin-33 (IL-33; HF-NEV; IL-1F11), a member of the IL-1 family of cytokines, is expressed by many cell types following pro-inflammatory stimulation and is thought to be released on cell lysis. The 30kDa human IL33 is converted by CASP1 to a 18kDa protein. IL33 binds to and signals through ST2 (IL1R1) and its stimulation recruits MYD88, IRAK, IRAK4, and TRAF6, followed by phosphorylation of ERK1 (MAPK3)/ERK2 (MAPK1), p38 (MAPK14), and JNK. The ability of IL-33 to target numerous immune cell types, like Th2-like cells, mast cells, and B1 cells, and to induce cytokine and chemokine production underlines its potential in influencing the outcome of a wide range of diseases, such as arthritis, asthma, atopic allergy & anaphylaxis, cardiovascular disease/atherosclerosis, nervous system diseases, and sepsis.
宿主来源:
E. coli
靶标/特异性:
Binds to mouse and human ST2.
保存温度:
+4°C
运输温度:
BI
预期分子量:
~20kDa (SDS-PAGE)
产品形式:
liquid
存储溶液:
Liquid. 0.2µm-filtered solution in 55mM TRIS-Cl, pH 8.2, containing 150mM NaCl.
产地:
瑞士
纯度:
>90% (SDS-PAGE)
生物活性:
Activates mouse and human ST2-dependent NF-kappaB pathway.
内毒素水平:
<1EU/µg purified protein (LAL test; Lonza).
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