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折扣/货期| 货号：AG-40B-0096-3010 | 规格：3 x 10 ug | 目录价：￥3840 |
| 货号：AG-40B-0096-C010 | 规格：10 ug | 目录价：￥1920 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
IL-36Ra (aa 3-156) (mouse) (rec.) (untagged)
别名:
Interleukin-36 Receptor Antagonist Protein; IL-1F5; Interleukin-1 Family Member 5; IL-1delta; Interleukin-1delta; Interleukin-1 Homolog 3; Interleukin-1-like Protein 1
产品描述:
IL-36Ra/IL-1F5 is a highly and a specific antagonist of the IL-1 receptor-related protein 2-mediated response to IL-36alpha (IL-1F6), IL-36beta (IL-1F8) and IL-36gamma (IL-1F9). These cytokines bind to IL-36R (IL-1Rrp2) and IL-1RAcP, activating similar intracellular signals as IL-1. IL-36Ra inhibits the production of proinflammatory cytokines, including IL-12, IL-1beta, IL-6, TNF-alpha and IL-23 induced by IL-36 in BMDC and CD4 T cells. Skin and dendritic cells are target of the IL-36 interleukins leading to a Th1 response. Recently mutations that affect the levels and the activity of IL-36Ra have been found in patients with pustular psoriasis, leading to enhanced production of inflammatory cytokines (IL-8 in particular) by keratinocytes.
宿主来源:
E. coli
产品浓度:
0.1mg/ml after reconstitution
保存温度:
+4°C
运输温度:
BI
预期分子量:
~17kDa
产品形式:
solid
存储溶液:
Lyophilized. Contains PBS.
产地:
瑞士
纯度:
>95% (SDS-PAGE)
生物活性:
Inhibits the IL-6 induced expression of IL-36alpha (IL-1F6), IL-36beta (IL-1F8), and IL-36gamma (IL-1F9) in BMDCs. 1µg/ml of IL-36Ra inhibits the activity of 10 ng to 100 ng/ml of the agonists.
内毒素水平:
<0.05EU/µg purified protein (LAL test; Lonza).
促销活动
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