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折扣/货期| 货号：AG-40A-0191Y-3010 | 规格：3 x 10 ug | 目录价：￥5520 |
| 货号：AG-40A-0191Y-C010 | 规格：10 ug | 目录价：￥2760 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
IL-38 (human) (rec.) (His)
别名:
Interleukin-38; Interleukin-1 Family Member 10 theta; IL-1F10; FIL1 theta; FKSG75; IL-1HY2; IL1-theta; Interleukin-1 HY2; Interleukin-1 Receptor Antagonist FKSG75
产品描述:
IL-38 (IL-1F10) mRNA is expressed in heart, placenta, fetal liver, spleen, thymus and tonsil. The expression in a variety of immune tissues and similarity to IL-1Ra suggest a role of IL-1F10 in the inflammatory response. It has been reported that removal of the N-terminus domain of the interleukins of the IL-1F family such as IL-1F5 / 6 / 8 or 9 (also called IL-36Ra, IL-36alpha, IL-36beta or IL-36gamma) is important to increase their biological activity. Recently it has been shown that IL-38 is N-terminally processed and secreted by apoptotic cells. Released processed IL-38 (20-152) binds to the receptor Interleukin-1 receptor accessory protein-like 1 (IL1RAPL1; TIGIRR-2) at the surface of macrophages. Processed IL-38-activated IL1RAPL1 reduces the production of IL-6 leading to inflammation attenuation.
宿主来源:
E. coli
产品浓度:
After reconstitution:for 10µg size: 0.1mg/ml
保存温度:
+4°C
运输温度:
BI
预期分子量:
~18kDa (SDS-PAGE)
产品形式:
solid
存储溶液:
Lyophilized. In 50mM TRIS-Cl, pH 8.0, containing 150mM NaCl.
产地:
瑞士
纯度:
>95% (SDS-PAGE)
内毒素水平:
<1EU/µg purified protein (LAL test; Lonza).
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