IL12B / IL12 p40 antibody [C17-8] (PE)-单抗-深圳欣博盛生物科技有限公司

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IL12B / IL12 p40 antibody [C17-8] (PE)

品牌：GeneTex

官网链接

说明书

折扣/货期

货号：GTX01491-08

规格：100μg

目录价：￥3600

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

IL12B / IL12 p40 antibody [C17-8] (PE)

别名:

interleukin 12a , interleukin 12b , IL-12p35 , Il-12a , Ll12a , p35 , Il-12b , Il-12p40 , Il12p40 , p40

产品描述:

The C17.8 antibody is specific for the 40 kDa (p40) protein subunit shared by the cytokines IL-12 and IL-23. To form IL-12, p40 assembles with a separate 35 kDa protein known as p35, resulting in a 70 kDa functional cytokine. IL-12 is secreted by activated monocytes, macrophages, and dendritic cells, and has been shown to target naive, resting CD4+ T cells to promote their proliferation and secretion of cytokines. IL-23 contains the p40 subunit in combination with a 19 kDa protein chain, p19; its primary source being activated dendritic cells and other antigen-presenting cells. IL-23 appears to target different cell types than IL-12, acting on memory CD4+ T cells to induce a strong proliferative response and contributing to the generation and expansion of Th17 cells. Like the cytokines themselves, the receptors for IL-12 and IL-23 share one subunit, as well as containing distinct cytokine-specific subunits.As the C17.8 antibody binds to a shared subunit of both IL-12 and IL-23, it may be used as a marker for either IL-12 or IL-23 expression in dendritic cells, monocytes and macrophages, and is widely used for neutralization of activity associated with either cytokine.

反应种属:

Mouse

宿主来源:

Rat

实验应用:

FCM

同种型:

IgG2a

克隆性:

Monoclonal

克隆号:

C17-8