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折扣/货期| 货号：GTX25370 | 规格：50μg | 目录价：￥5000 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
Insulin Receptor beta antibody [CT-1]
别名:
insulin receptor , CD220 , HHF5
反应种属:
Human, Mouse, Rat
宿主来源:
Mouse
实验应用:
ELISA, IP, Purification
靶标/特异性:
This antibody is specific for the approximately 95 kDa IR and shows no cross-reactivity with insulin like growth factor (IGF) receptors. Phosphorylation of the threonine residue within this sequence (corresponding to threonine 1348) decreases the affinity of this antibody for IR by approximately 100 fold. This antibody reacts with autophosphorylated IR, unoccupied IR, and the insulin IR complex. It has no effect on insulin-stimulated autophosphorylation.
同种型:
IgG1
免疫原:
A 15-mer synthetic peptide corresponding to aa Tyr-KKNGRILTLPRSNPS from the C-terminal of human insulin receptor β-subunit
克隆性:
Monoclonal
克隆号:
CT-1
纯化方式:
Unpurified
偶联:
Unconjugated
产品浓度:
保存温度:
Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC. DO NOT FREEZE.
运输温度:
4°C
产品形式:
Liquid
生产商:
GeneTex
功能与背景:
This gene encodes a member of the receptor tyrosine kinase family of proteins. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that form a heterotetrameric receptor. Binding of insulin or other ligands to this receptor activates the insulin signaling pathway, which regulates glucose uptake and release, as well as the synthesis and storage of carbohydrates, lipids and protein. Mutations in this gene underlie the inherited severe insulin resistance syndromes including type A insulin resistance syndrome, Donohue syndrome and Rabson-Mendenhall syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]
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