Interleukin 18 Antibody / IL-18-单抗-深圳欣博盛生物科技有限公司

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Interleukin 18 Antibody / IL-18

品牌：NSJ Bio

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说明书

折扣/货期

货号：V5596SAF-100UG

规格：100 ug

目录价：￥6652.1

产品详情

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产品名称:

Interleukin 18 Antibody / IL-18

产品描述:

Four structurally related IL-1 receptor ligands have been described. These include three agonists designated IL-1a, IL-1b and IL-1g/IL-18 and a specific receptor antagonist, IL-1Ra. IL-1a and IL-1b play critical roles in the regulation of the immune response and inflammation, serving as activators of T and B lymphocytes and NK (natural killer) cells. IL-18 (also referred to as IL-1g) has been shown to augment the secretion of IFN-g from T lymphocytes and increase NK cell activity in spleen cells. IL-18 exhibits 19% and 12% identity with IL-1a and IL-1b respectively over the 12 beta-strands of the beta-trefoil fold domain, which is a signature feature of the IL-1 family. The unusual leader sequence of IL-18 may be analogous to the IL-1b pro-domain which must be cleaved by the serine protease ICE for optimal secretion and biological activity. Originally described as IGIF (IFN-g-inducing factor), IL-18 is induced by mouse liver subsequent to challenge with lipopolysaccharide (LPS).

反应种属:

Human

宿主来源:

Mouse

实验应用:

IHC-P, WB

同种型:

Mouse IgG2a, kappa

免疫原:

A recombinant fragment (within amino acids 1-193) of human IL-18 protein was used as the immunogen for the Interleukin 18 antibody.

克隆性:

Monoclonal (mouse origin)